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Metabolic control theory: its role in microbiology and biotechnology

Douglas B. Kell, Hans V. Westerhoff
DOI: http://dx.doi.org/10.1111/j.1574-6968.1986.tb01863.x 305-320 First published online: 1 October 1986


Many areas of microbiology and biotechnology are directly concerned with the isolation, study or engineering of cells capable of (over)producing metabolites of commercial significance. Yet the study, production or improvement of such strains has often been at best semi-empirical. The metabolic control theory developed by Kacser, Burns, Heinrich and Rapoport can provide a rational and quantitative basis for the description and improvement of such processes.

  • Flux control
  • optimisation
  • elasticity
  • concentration control
  • productivity
  • metabolism
  • genetic engineering

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